To the saints (the consecrated people of God) and believing and faithful brethren in Christ who are at Colossae: Grace (spiritual favor and blessing) to you and [heart] peace from God our Father.

And God purposed that through (by the service, the intervention of) Him [the Son] all things should be completely reconciled back to Himself, whether on earth or in heaven, as through Him, [the Father] made peace by means of the blood of His cross.

And let the peace (soul harmony which comes) from Christ rule (act as umpire continually) in your hearts [deciding and settling with finality all questions that arise in your minds, in that peaceful state] to which as [members of Christ’s] one body you were also called [to live]. And be thankful (appreciative), [giving praise to God always].