ESV Reformation Study Bible – Dan 8:4
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Dan 8:4

8:4 charging westward and northward and southward. That is, his back was toward the east from where he had come (Is. 41:2). Cyrus first took Asia Minor, then northern and southern Mesopotamia. Subsequent rulers extended Medo-Persian control far to the East.

became great. The Persian Empire became larger than any previous empire in ancient Near Eastern history.