4:6 do not be anxious about anything. Although the same word is used in 2:20 of a loving concern for others, here it denotes an anxiety that is incompatible with trust in God.

in everything. Paul’s language is deliberately all-inclusive; there are no restrictions on applying it.

prayer and supplication with thanksgiving . . . requests. The four terms used here make up two couplets. Paul is not defining separate types of prayers. Rather, the cluster of words shows what importance he attaches to the practice of prayer. Presenting requests in prayer provides an outlet for anxiety (1 Pet. 5:7). Doing so “with thanksgiving” is itself an antidote to worry.